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Betting on Better Humans: Inside Exceptional Ventures’ Health & Longevity Playbook

Paolo Pio on why his mission-driven fund is scaling to 200+ founders to extend human joy

Welcome to a new episode of the EUVC Podcast, where we bring you the people and perspectives shaping European venture.

This week, Andreas Munk Holm sits down with Paolo Pio, co-founder and Managing Partner at Exceptional Ventures — a mission-driven early-stage fund investing in the future of human health, fitness, nutrition, and longevity.

Paolo shares how a personal obsession with sleep, metabolism, and fitness evolved into a structured thesis for investing in businesses and technologies that help us live better, longer — and how Exceptional Ventures plans to back over 200 founders across three funds to deliver returns that match the mission.


🎯 This Episode’s Themes:

  • Why health, fitness, and prevention are ripe for VC investment

  • How personalized, continuous monitoring unlocks true wellness

  • The 4-pillared thesis: prevention, early detection, smarter care & delivery

  • Lessons from Fund I: 3,600 companies reviewed → 37 investments

  • The case for “high-volume VC” in Europe: why more bets matter

  • From sleep hygiene to nanobots: the future of health innovation

  • Community, LPs, and morning workouts at SuperVenture


Here’s what’s covered:

  • 01:00 | The Mission: Improving the human joy path through health & longevity

  • 03:00 | Why Now: Obesity, metabolic health & the need for smarter prevention

  • 05:00 | The Four Pillars: Sleep, exercise, early detection & delivery innovation

  • 08:00 | Exceptional’s Model: Fund I learnings, Fund II targets, Fund III ambitions

  • 10:00 | The Volume Bet: Why Europe needs funds backing 50+ startups per cycle

  • 12:00 | Sourcing & Screening: From 3,600 companies to 37 portfolio bets

  • 15:00 | Backing Founders on the Edge: From glucose monitoring to rural US clinics

  • 18:00 | The Big Vision: 200+ founders backed, 30,000+ community members

  • 21:00 | Big LP Names & Co-Investors: How the wider venture stack leans in

  • 24:00 | Why Community Matters: The morning workouts, the events, the energy

  • 27:00 | Longevity & Fund IV: Why the best is still ahead

📺 Watch the episode here or stream it on Spotify or Apple Podcasts—now with chapters for easy navigation 🎧


✍️ Show Notes

A Personal Mission Turned Thesis

Paolo and co-founder Matt built Exceptional Ventures on a simple conviction: human joy and health go hand-in-hand. From sleep to nutrition to the next-gen care stack, they’re betting big that prevention beats treatment.


Why Volume Wins

Exceptional bucked Europe’s old-school low-volume model by doing 37 deals in Fund I — and plans 50–60 in Fund II, with 90+ in Fund III. More shots on goal, more founders backed, more shots at generational winners.


Prevention to Nanobots: Where the Thesis Goes Next

Continuous monitoring, personalized metabolic insights, and smarter delivery are just the beginning. Expect telemedicine, AI, and even brain-computer interfaces to play a role.


Morning Workouts & Mission-Driven LPs

Exceptional’s community isn’t just LPs and founders — it’s a global tribe obsessed with living well. From SuperVenture workouts to Italian Tech Week, the vibe is different — and so is the ambition.


💡 Investor Takeaway

Europe needs bigger swings at category-defining health & longevity startups — and Exceptional Ventures is showing how mission and volume can go hand in hand.

Dario combines deep institutional, operational, and investment expertise, investing in early-stage companies and funds. Recognized as a "40 Rising Star under 40" by VCJ, he actively contributes to the industry.

Before founding LTV Capital, Dario co-led fund investments at Anthemis Group, a top fintech investor, where he developed early-stage fintech plays with BBVA and pioneered a media-financial services fund. His background also includes spearheading international expansion at emerging markets fintech JUMO and contributing to the creation of ROAM, now Africa's largest classifieds group.

Academically, he holds a Master of Business Science in Finance from the University of Cape Town; his dissertation on "Tencent Holdings Limited" is widely downloaded and cited.

Outside of work, Dario is a former 125cc motorcycle racing champion who now advises the Finetwork Mir Racing Team, supporting young talent in motorsports. He is driven by a passion for empowering others and fostering change in the emerging manager VC ecosystem.

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