In this episode, Andreas Munk Holm is joined by Jeremy Uzan, co-founder and GP at Singular, for a look at how a “plain vanilla” approach to venture—driven by deep founder focus and relentless performance orientation — can be a powerful advantage.
Together, they unpack the mechanics behind Singular’s model, how the team stays agile without a rigid thesis, and what it means to create an empowering internal culture. Singular is an early-stage venture capital firm born in Europe, committed to empowering European founders with global ambitions across all sectors, from Seed to Series B, with a strong focus on Series A companies.
Jeremy also shares his evolving views on European talent, the rise of Paris as a startup epicenter, and why he believes we’re only just beginning to unlock the entrepreneurial potential of Europe’s scientific minds.
Here’s what’s covered:
02:00 – Should Generalist VCs Still Exist in Europe?
07:10 – Fundraising Like a Founder: How LPs Backed Fund I and II
14:00 – Why Generalist Isn’t a Weakness—It’s Strategic
16:25 – Diversification vs. Focus: Squaring LP Needs with Performance
21:15 – Temporary Specialists: Sprinting Deep Into Sectors
24:20 – From Zero to One on Markets: Learning via Founders
27:15 – European Talent Post-COVID: What’s Changed
30:00 – Paris Joins the Core of the European Ecosystem
35:15 – The Rise of Science Entrepreneurs in Europe
39:00 – Why Bio is the Next Big Tech Frontier
📺 Watch the episode here or stream it on Spotify or Apple Podcasts—now with chapters for easy navigation 🎧
✍️ Show Notes
Singular’s Thesis: Performance First
Jeremy pulls back the curtain on how Singular operates without a fixed investment thesis. Instead, they obsess over finding the best founding teams—wherever they emerge—and chase performance above all else. It's a fund that prizes instinct, adaptability, and trust in human potential.
Empowerment, Not Hierarchy
From open ICs to a feedback-rich culture, Singular emphasizes empowerment at every level. Analysts speak, partners listen, and decisions are collective. Jeremy sees this not just as good management but as a core part of the investment edge.
Temporary Specialization: Why It Works
Rather than commit to a vertical indefinitely, Singular pursues “deep dive sprints” into emerging spaces, like sovereign compute or techbio, when the timing and talent align. This agile approach lets them stay responsive to science, tech, and regulatory inflections.
Europe’s Changing Founder Landscape
Jeremy discusses the evolution of the European startup scene post-COVID-19, especially the rise of Paris as a more integrated, ambitious hub. With repeat founders, global mindsets, and new governance standards, the maturity shift is palpable.
Betting on the Bio Wave
The episode closes with a biology exploration as the next deep tech wave. Jérémy explains why techbio is becoming too compelling to ignore—and how it marks the beginning of a broader movement of science entrepreneurs ready to build at scale.
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